MEDICOLEGAL IMPORTANCE FOR USING DIFFERENT ROUTES OF ADMINISTRATION OF MISOPROSTOL IN MEDICAL ABORTION: A RANDOMIZED CONTROLLED TRIAL

Authors

  • Mohamed S. Hemeda1, Heba Youssef Sayed1, Moustafa M. Ibrahim2,Abdel Rahman Z. Abdel Rahman2, Alsayed Magdi Alsayed Farahat2,Hatem Ali Ahmed Abdelmottaleb2,Mohamed Anwer Mohamed2,Mohamed Mahmoud Hussein Hassanein2, Mona Ibrahim Elyamany3, Ahmed Abd Elhamid4, El-Ashmawy A4, Mohamed Salah Abdelhamed5, Emad Ahmed Abdelmooty5. Ibrahim Arafa Reyad Arafa6. Author

Abstract

Background: Investigating accessible and secure procedures for medical abortion is crucial in poor nations. Misoprostol is frequently used in obstetrics and gynecology to induce abortion, prime the cervical mucosa, and perform medical abortions. This study aimed to investigate the effectiveness of various misoprostol administration methods in medical abortion.

Patients and Methods: Women seeking pregnancy termination within the gestational age limit of the study were recruited and randomly assigned to one of four groups: oral, sublingual, vaginal, or buccal administrations, A sample size of 112 was planned to detect a 4-hour reduction in abortion time. Statistical analysis was performed using R software for Windows.

Results: Among the various administrative groups, the success percentages differed. The groups who received the medication orally (92%), sublingually (95%), vaginally (90%), and buccally (93%), all had success rates relative to each other. Nonetheless, P> 0.05 indicated that there was no statistically significant difference in the success rates across the groups.

Conclusion: All misoprostol administration routes showed high success rates for abortion induction with minimal need for additional interventions. However, sublingual misoprostol demonstrated the most favorable profile with the lowest need for additional interventions and average side effect rates.

 

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Published

2024-01-22

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Articles

How to Cite

MEDICOLEGAL IMPORTANCE FOR USING DIFFERENT ROUTES OF ADMINISTRATION OF MISOPROSTOL IN MEDICAL ABORTION: A RANDOMIZED CONTROLLED TRIAL. (2024). Neuropsychopharmacologia Hungarica, 22(1), 250-262. http://neuropsychopharmacologiahungarica.com/index.php/NPPH/article/view/225