IMPACT OF PRIOR COVID-19 INFECTION ON SODIUM IODIDE SYMPORTER GENE EXPRESSION AND INFLAMMATION IN HYPERTHYROIDISM PATIENTS UNDERGOING THYROIDECTOMY

Authors

  • Hakeem Ghani Hassan, Zainab Hakeem Ghani Author

Abstract

Background: COVID-19 can perturb thyroid regulation during and after acute infection. However, few studies have examined potential residual effects of cleared COVID-19 illness on thyroid function. We aimed to analyze sodium iodide symporter (NIS) gene expression, autoimmunity markers, and inflammation in Graves' disease hyperthyroidism patients with recent COVID-19 history versus uninfected controls.

Objectives: To compare NIS gene levels, thyroid autoantibodies, and inflammatory cytokines between 50 hyperthyroid patients with preceding COVID-19 in past 3 months and 50 matched hyperthyroid controls without prior exposure.

Methods: We measured NIS and GAPDH mRNA levels in thyroid tissue samples from hyperthyroid patients who underwent thyroidectomy using qPCR. Serum samples were analyzed for TSH receptor antibodies (TRAb), thyroid peroxidase antibodies (TPOAb), TNF-alpha and IL-6 by immunoassays.

Results: The COVID-recovered group showed markedly reduced NIS expression (higher ΔCt) indicating impaired iodide uptake capacity relative to controls (p=0.00001). TPOAb titers were mildly elevated post-COVID-19 (p=0.00001) whereas TRAb were similarly raised in both groups (p=0.8642), signifying unaffected Graves' pathogenesis. TNF-alpha and IL-6 levels were significantly higher after COVID-19 (both p=0.00001) reflecting enduring inflammation.

Conclusion: Hyperthyroid patients recovering from COVID-19 exhibit suppressed NIS expression, heightened thyroid directed autoimmunity, and sustained proinflammatory activation months later - changes plausibly underpinning residual thyroid dysfunction. Closer monitoring of post-viral thyroid abnormalities is warranted in this vulnerable subset.

 

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Published

2024-01-20

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How to Cite

IMPACT OF PRIOR COVID-19 INFECTION ON SODIUM IODIDE SYMPORTER GENE EXPRESSION AND INFLAMMATION IN HYPERTHYROIDISM PATIENTS UNDERGOING THYROIDECTOMY. (2024). Neuropsychopharmacologia Hungarica, 22(1), 263-278. http://neuropsychopharmacologiahungarica.com/index.php/NPPH/article/view/227