EVALUATION OF PROLINE LEVEL AS A POTENTIAL BIOMARKER AND ITS CORRELATION WITH STANDARD MARKERCA15˗3IN PATIENTS WITH BREAST TUMOR

Authors

  • Raghdaa Adnan Syabakhash ¹, Raid J. M. Al-Timimi2,Qahtan A. Mahdi. 3 Author

Abstract

Iraqi women have had more cancers of the breast in recent years. To achieve successful treatment, delay dissemination, and reduce fatalities in breast cancer, the best way is to monitor protein levels in body fluids for early diagnosis and prognosis.The objective of the present research was to determine the diagnostic and prognostic significance of proline as a marker in individuals diagnosed with breast cancerTo examine the correlations between proline and the established biomarker CA 15-3, as well as clinicopathological characteristics. This research involved 30 newly diagnosed female with breast cancer before surgical operation and compare with their levels after one month of the surgical operation, and 28femalehad noncancerous breast tumors as control subjects. CA15˗3was measuredby ELISA technique and proline level by HPLC technique.A notable variations in the average proline levels was observed between the categories of study participants; the benign group exhibited the highest level, then post-operative category, and finally the newly diagnosed category.Additionally, notable variations were observed in the average CA-15-3 levels with the newly diagnosed category having the highest level, then the post-operative category and then benign category.Proline concentration showed a significant positive correlation with CA15-3 in malignant and benign groups. Both of Proline & CA-15-3 were strong predictors by ROC, 100% & 90%for Proline, 93% &93%, for CA-15-3 respectively.

 

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Published

2024-01-20

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How to Cite

EVALUATION OF PROLINE LEVEL AS A POTENTIAL BIOMARKER AND ITS CORRELATION WITH STANDARD MARKERCA15˗3IN PATIENTS WITH BREAST TUMOR. (2024). Neuropsychopharmacologia Hungarica, 22(1), 313-327. http://neuropsychopharmacologiahungarica.com/index.php/NPPH/article/view/249